購(gòu)物車
幫助
021-54845833/15800441009
中文名稱： UNC13B 抗原（重組蛋白）
英文名稱： UNC13B Antigen (Recombinant Protein)
別 名： unc-13 homolog B; UNC13; MUNC13; Unc13h2; munc13-2
相關(guān)類別：抗原
儲(chǔ) 存： 冷凍（-20℃）
概 述
|
Full name: |
unc-13 homolog B |
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Synonyms: |
UNC13; MUNC13; Unc13h2; munc13-2 |
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Swissprot: |
O14795 |
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Gene Accession: |
BC111781 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. |
