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中文名稱：兔抗STUB1多克隆抗體

英文名稱： Anti-STUB1 rabbit polyclonal antibody

別名： STUB1; CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1

相關(guān)類別：一抗

儲存： 冷凍（-20℃）避光

宿主： Rabbit

抗原： STUB1

反應(yīng)種屬： Human, Mouse, Rat

標(biāo) 記物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

The carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to the ubiquitin proteasome system. Cytoplasmic CHIP protein contains three 34-amino acid TPR (tetratricopeptide repeat) domains at its amino terminus and a carboxy-terminal U-box domain. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, while E3 ubiquitin ligase activity is confined to the U-box domain. The binding of CHIP to Hsp70 can stall the folding of Hsp70 client proteins and concomitantly facilitate the U-box dependent ubiquitination of Hsp70-bound substrates. CHIP appears to play a central role in cell stress protection and is responsible for the degradation of disease-related proteins that include cystic fibrosis transmembrane conductance regulator, p53, huntingtin and Ataxin-3, Tau protein, and α-synuclein.

Applications:

WB

Name of antibody:

STUB1

Immunogen:

Fusion protein of human STUB1

Full name:

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

Synonyms：

STUB1; CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1

SwissProt:

Q9UNE7

WB Predicted band size:

35 kDa

WB Positive control:

HeLa, PC12, COS1, COS7 and OVCAR3 cells, muscle and liver tissue

WB Recommended dilution:

500-2000

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兔抗STUB1多克隆抗體

Background:	The carboxy terminus of Hsc70-interacting protein (CHIP, STUB1) is a co-chaperone protein and functional E3 ubiquitin ligase that links the polypeptide binding activity of Hsp70 to the ubiquitin proteasome system. Cytoplasmic CHIP protein contains three 34-amino acid TPR (tetratricopeptide repeat) domains at its amino terminus and a carboxy-terminal U-box domain. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain, while E3 ubiquitin ligase activity is confined to the U-box domain. The binding of CHIP to Hsp70 can stall the folding of Hsp70 client proteins and concomitantly facilitate the U-box dependent ubiquitination of Hsp70-bound substrates. CHIP appears to play a central role in cell stress protection and is responsible for the degradation of disease-related proteins that include cystic fibrosis transmembrane conductance regulator, p53, huntingtin and Ataxin-3, Tau protein, and α-synuclein.
Applications:	WB
Name of antibody:	STUB1
Immunogen:	Fusion protein of human STUB1
Full name:	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Synonyms：	STUB1; CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1
SwissProt:	Q9UNE7
WB Predicted band size:	35 kDa
WB Positive control:	HeLa, PC12, COS1, COS7 and OVCAR3 cells, muscle and liver tissue
WB Recommended dilution:	500-2000