購(gòu)物車(chē)
幫助
021-54845833/15800441009
中文名稱：兔抗RAF1多克隆抗體
英文名稱： Anti-RAF1 rabbit polyclonal antibody
別 名： NS5; CRAF; Raf-1; c-Raf
抗 原： RAF1
儲(chǔ) 存： 冷凍（-20℃）
宿 主： Rabbit
相關(guān)類(lèi)別： 一抗
反應(yīng)種屬： Human, Mouse, Rat
標(biāo)記物： Unconjugate
克隆類(lèi)型： rabbit polyclonal
技術(shù)規(guī)格
|
Background: |
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. |
|
Applications: |
ELISA, WB, IHC |
|
Name of antibody: |
RAF1 |
|
Immunogen: |
Fusion protein of human RAF1 |
|
Full name: |
Raf-1 proto-oncogene, serine/threonine kinase |
|
Synonyms： |
NS5; CRAF; Raf-1; c-Raf; CMD1NN |
|
SwissProt: |
P04049 |
|
ELISA Recommended dilution: |
5000-10000 |
|
IHC positive control: |
Human colon cancer |
|
IHC Recommend dilution: |
25-100 |
|
WB Predicted band size: |
73 kDa |
|
WB Positive control: |
Mouse muscle tissue and Hepg2 cell |
|
WB Recommended dilution: |
500-2000 |
