購(gòu)物車
幫助
021-54845833/15800441009
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Background: |
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). |
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Applications: |
WB |
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Name of antibody: |
EGLN1 |
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Immunogen: |
Fusion protein of human EGLN1 |
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Full name: |
egl-9 family hypoxia inducible factor 1 |
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Synonyms: |
HPH2; PHD2; SM20; ECYT3; HALAH; HPH-2; HIFPH2; ZMYND6; C1orf12; HIF-PH2 |
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SwissProt: |
Q9GZT9 |
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WB Predicted band size: |
46 kDa |
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WB Positive control: |
OVCAR8, COS7, U2OS, SH-SY5Y and Hela cells |
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WB Recommended dilution: |
500-2000 |
