購(gòu)物車
幫助
021-54845833/15800441009
中文名稱：MLKL抗原（重組蛋白）
英文名稱： MLKL Antigen (Recombinant Protein)
別 名： hMLKL
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 1-263 amino acids of human MLKL |
|
Full name: |
mixed lineage kinase domain like pseudokinase |
|
Synonyms: |
hMLKL |
|
Swissprot: |
Q8NB16 |
|
Gene Accession: |
BC028141 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. |
