購物車
幫助
021-54845833/15800441009
中文名稱：PLOD2 抗原（重組蛋白）
英文名稱： PLOD2 Antigen (Recombinant Protein)
別 名： procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; LH2; TLH; BRKS2
儲(chǔ) 存： 冷凍（-20℃）
相關(guān)類別： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 538-737 amino acids of human PLOD2 |
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Full name: |
procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 |
|
Synonyms: |
LH2; TLH; BRKS2 |
|
Swissprot: |
O00469 |
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Gene Accession: |
BC037169 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. |
