購物車
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021-54845833/15800441009
中文名稱：IDE抗原（重組蛋白）
英文名稱： IDE Antigen (Recombinant Protein)
別 名： INSULYSIN
儲 存： 冷凍（-20℃）
相關類別： 抗原
概述
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Fusion protein corresponding to a C terminal 300 amino acids of human IDE |
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Full name: |
insulin-degrading enzyme |
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Synonyms: |
INSULYSIN |
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Swissprot: |
P14735 |
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Gene Accession: |
BC096336 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified. |
