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  • STAT6抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW17762
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:75
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中文名稱:STAT6抗原(重組蛋白)

英文名稱: STAT6 Antigen (Recombinant Protein)

儲      存: 冷凍(-20℃)

相關(guān)類別: 抗原

概述

Fusion protein corresponding to a region derived from 530-847 amino acids of human STAT6


技術(shù)規(guī)格

Full name:

signal transducer and activator of transcription 6, interleukin-4 induced

Synonyms:

STAT6B; STAT6C; D12S1644; IL-4-STAT

Swissprot:

P42226

Gene Accession:

BC075852

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.


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